east african genetics bodybuilding

2016; Lorente-Galdos et al. Furthermore, Y chromosomal haplogroups are genetically more diverse in nomadic pastoralists groups, whereas mtDNA haplogroups are more diverse in sedentary farmers (kov et al. Now that we know more about DNA, genes, and health, it is clear that some people are born with a boost in the muscle department. 2021). However, the magnitude of the sex bias is difficult to pinpoint from X chromosomal and autosomal ancestry proportions due to potential confounding from complex demographic histories, among others (Pfennig and Lachance 2023). An additional eastsouthwest cline was recently identified by the incorporation of six novel genomes of ancient huntergatherers from eastern and southcentral Africa. American and East Africans have the same height and weight but East Africans are the ones with much bigger muscles. Lastly, small amounts of admixture among Sahelian groups have been inferred from genome-wide markers (Fortes-Lima et al. Given the high genetic affinity of a pastoralist individual who lived 4000 years ago in northern Sudan with ancient individuals from Kenya and Tanzania, it has been argued that this initial dispersal of northeastern pastoralists into East Africa occurred rapidly (Wang et al. Watch popular content from the following creators: zach.cali18(@zach.cali18), S A L I M(@sallfitt), NICK(@nick.zelko), rose(@3r0sy), Arya Ziaee(@notthatarya), KhaledLifts(@khaledlifts), Ihsan Ghareeb(@sean97antwan), AliHach_21(@alihach_21), Abed(@abedbrah), What determines levels of mitochondrial genetic diversity in birds? This study found that Tunisian Imazighen trace all their ancestry to an autochthonous North Africanthe so-called Maghrebiancestral component, whereas all Arab populations also have European-related, Middle Easternrelated, and/or sub-Saharanrelated ancestry (Henn et al. In sub-Saharan Africa, strong selection for malaria resistance has contributed to the near fixation of the Duffy blood group, elevated rates of G6PD deficiency, and sickle cell disease (Kariuki and Williams 2020). In contrast, there was a significant Eurasian paternal contribution (71.4%) defined by haplogroups R/I/G/N/O/J in the same group, and the Western European R1b haplogroup was prevalent at 44.4%. (2021) found that fine-scale genetic substructure among seBSPs in South Africa correlates well with geography and linguistics and persists even after accounting for differential levels of Khoe-San admixture. 2017; Swart et al. 2017; Serra-Vidal et al. 2015) and allowing to narrow down causal variants (Jallow et al. When these East African men lived in the equatorial and tropical areas, they have an extremely high oxygen consumption rate, Which allowed them to store up the oxygen for quicker recovery from a workout. The fact East African people have the highest intermuscular fat percentage among all. Cladistic analysis of Bantu languages: a new tree based on combined lexical and grammatical data, A new paradigm: the African early iron age without Bantu migrations, Ancestry and disease in the age of genomic medicine, An ancestral recombination graph of human, neanderthal, and Denisovan genomes, Genetic adaptation to high altitude in the Ethiopian highlands, Genomic evidence for shared common ancestry of East African huntinggathering populations and insights into local adaptation, Genomic variation in seven Khoe-San groups reveals adaptation and complex African history, Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago, Khoe-San genomes reveal unique variation and confirm the deepest population divergence in homo sapiens, Tales of human migration, admixture, and selection in Africa, Stronger signal of recent selection for lactase persistence in Maasai than in Europeans, On the evolution of lactase persistence in humans, Along the Indian ocean coast: genomic variation in Mozambique provides new insights into the Bantu expansion, Genetic substructure and complex demographic history of South African Bantu speakers, Heterogeneity in Palaeolithic population continuity and Neolithic expansion in North Africa, Whole-genome-sequence-based haplotypes reveal single origin of the sickle allele during the Holocene wet phase, The missing diversity in human genetic studies, Taste perception and lifestyle: insights from phenotype and genome data among Africans and Asians, Reconstructing prehistoric African population structure, Whole Y-chromosome sequences reveal an extremely recent origin of the most common North African paternal lineage E-M183 (M81), Localization of adaptive variants in human genomes using averaged one-dependence estimation, Local ancestry adjusted allelic association analysis robustly captures tuberculosis susceptibility loci, Prospective avenues for human population genomics and disease mapping in Southern Africa, Whole-genome sequencing of Bantu-speakers from Angola and Mozambique reveals complex dispersal patterns and interactions throughout sub-Saharan Africa, The genetic structure and history of Africans and African Americans, Extensive admixture and selective pressure across the Sahel belt, Fine-scale human population structure in Southern Africa reflects ecogeographic boundaries, Ancestral mitochondrial N lineage from the Neolithic green Sahara, Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations, Sociocultural behavior, sex-biased admixture, and effective population sizes in Central African pygmies and non-pygmies, Male-biased migration from East Africa introduced pastoralism into Southern Africa, Genetic affinities among Southern Africa hunter, gatherers and the impact of admixing farmer and herder populations, Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait, Identification of African-specific admixture between modern and archaic humans, Ancient genomes reveal complex patterns of population movement, interaction, and replacement in sub-Saharan Africa, 4000-Year-old hair from the Middle Nile highlights unusual ancient DNA degradation pattern and a potential source of early Eastern Africa pastoralists, Tracking human population structure through time from whole genome sequences, An integrated personal and population-based Egyptian genome reference, Archaic hominin introgression in Africa contributes to functional salivary MUC7 genetic variation, Strong selection at MHC in Mexicans since admixture. In light of this, we call for more (responsibly conducted) studies of genetic variation in Africa and research capacity building on the African continent. 2011; Ndadza et al. 2016; Bergstrm et al. 2018). During the last few centuries, European colonization of the Cape by the Dutch, Germans, and French, later followed by British seizure and rule, contributed to the complex admixture patterns at the Western Cape. 2017; DAtanasio et al. Search for other works by this author on: The genetic architecture of adaptations to high altitude in Ethiopia, Berbers and Arabs: tracing the genetic diversity and history of Southern Tunisia through genome wide analysis, Evidence from Y-chromosome analysis for a late exclusively eastern expansion of the Bantu-speaking people, Recent historical migrations have shaped the gene pool of Arabs and Berbers in North Africa, A global reference for human genetic variation, Genetic structure and sex-biased gene flow in the history of southern African populations, Unraveling the complex maternal history of Southern African Khoisan populations, Leveraging genetic ancestry to study health disparities, Insights into human genetic variation and population history from 929 diverse genomes, Effect of NQO1 and CYP4F2 genotypes on warfarin dose requirements in HispanicAmericans and AfricanAmericans, Lactase persistence alleles reveal partial East African ancestry of southern African Khoe pastoralists, Genome-wide patterns of population structure and admixture in West Africans and African Americans, Admixture into and within sub-Saharan Africa Pickrell, JK, editor, Human adaptation, demography and cattle domestication: an overview of the complexity of lactase persistence in Africa, Human genomic diversity in Europe: a summary of human genomic diversity in Europe: a summary of recent research and prospects for the future, Demographic history and admixture dynamics in African Sahelian populations, A different view on fine-scale population structure in Western African populations, Identifying and interpreting apparent neanderthal ancestry in African individuals, Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method, Genome-wide association study of ancestry-specific TB risk in the South African Coloured population, Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans, High-depth African genomes inform human migration and health, Bantu-speaker migration and admixture in Southern Africa, Genetic structure of the western and Eastern African Sahel/Savannah belt and the role of nomadic pastoralists as inferred from the variation of D-loop mitochondrial DNA sequences, On the edge of Bantu expansions: mtDNA, Y chromosome and lactase persistence genetic variation in southwestern Angola, Loci associated with skin pigmentation identified in African populations, Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity, The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages, A panel of ancestry informative markers for the complex five-way admixed South African Coloured population, Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population, Genome-wide analysis of the structure of the South African Coloured population in the Western Cape, Circum-Saharan prehistory through the lens of mtDNA diversity, Farmers and their languages: the first expansions, Recovering signals of ghost archaic introgression in African populations. And they have other characteristics like high insulin sensitivity, lower insulin levels, and lower levels of insulin resistance. Specifically, Latin American genomes are enriched for African MHC/HLA haplotypes (Zhou et al. Subsequent admixture with European-like ancestry and Native American-like ancestry populations was spatially and temporally complex, leading to varying amounts of recent African-like ancestry in admixed populations in the Americas (Bryc et al. 2016; Patin et al. I also have the top 3 combat genes someone posted on here . Attempts to illuminate the deep population structure in Africa have been further aided by the emergence of ancient DNA from unadmixed huntergatherer individuals (e.g., Skoglund et al. Through this admixture event, the Fulani likely received a European LP variant 13910*T (rs4988235) in the LCT gene region that was then positively selected, reaching frequencies between 18% and 60% in Fulani groups (Lokki et al. Divergence times are based on estimates from Schlebusch et al. WebDesign, setting, and participants: This post hoc analysis of the SPRINT trial incorporated data from a multicenter study of self-identified Black participants with available West African ancestry proportion, estimated using 106 biallelic autosomal ancestry informative genetic markers. Thus, there were ample opportunities for admixture between modern humans and archaic hominins. Understanding how this population-specific genetic variation influences complex traits is particularly important in the context of polygenic scores. (2021). East Africans Genetics for Muscle Building, The difference between East Africans and other countries. 2016; Sol-Morata et al. Note that the results of ADMIXTURE analysis are contingent on which populations are included, as well as their sample sizes. AdmixtureThe interbreeding of individuals from two or more subpopulations that were isolated for a relatively short evolutionary time. As the ancestral homeland of our species, Africa contains elevated levels of genetic diversity and substantial population structure. of course you have other races who are not so blessed for 2015). Among Khoe-San groups, this East African LP SNP is found at the highest frequency in the Nama with a frequency of 35%, which is much higher than expected given the 13% East African admixture fraction in the Nama, suggesting positive selection (Breton et al. So my question is how common is it for a ethnic Somali to have these genes ? 3. 2016), African populations also exhibit signals of Neanderthal admixtureespecially northeastern African but also some West African populations (Gurdasani et al. Genetic ancestryThe genealogical paths through which an individual inherits DNA from specific ancestors in a reference population. Compared with the rest of the world, each African genome harbors 25% more polymorphisms than each non-African genome (Auton et al. 2. Greater numbers of private African alleles are consistent with the out-of-Africa (OOA) model, as substantial numbers of polymorphisms were lost due to serial founder effects. However, an FDA-approved test to inform the dosage of the anticoagulant warfarin surveys genetic variants that are not as relevant to Africans. 2022) as well as mtDNA and Y haplogroups (kov et al. 2020). The Sahel/Savannah belt was formed with the aridification of the Sahara Desert 5.5 kya (Manning and Timpson 2014), pushing human populations, among others, southward closer to the tropical rainforest, which demarcates the southern border of the belt. Where else may I get that type of info written in such an ideal method? WebDiscover short videos related to eastafricanbody on TikTok. A central premise of precision medicine is that ancestral variation plays a key role in disease processes. Note that we tried to refer to populations according to current naming conventions, and when we refer to admixture between specific populations, this does not necessarily imply the mixing of these exact populations, but rather the mixing of genetically similar populations. 2014; Choudhury et al. In contrast, the late-split hypothesis states that BSPs first migrated South through the rainforest before splitting into two groups, with one moving further South and the other one migrating East toward the Great African Lakes. Nevertheless, ancient DNA has recently been obtained of 18,000-year-old individuals (Lipson et al. 2012; Arauna et al. 2019). 2..The secret lies in certain parts of their DNA. WebThe dominance of East African distance runners and sprinters of West African origin invites discussion around the contribution of genetic and lifestyle factors to performance. 2020). Visual summary of key admixture events in Africa. 2020; Diallo et al. 2019; Schlebusch et al. However, the choice of reference populations for multiway admixed populations may be sensitive and critical in biomedical research (Chimusa et al. In line with archeological studies, genetic studies of Khoe-San confirmed that pastoralism spread from East Africa to southern Africa by demic diffusion (Breton et al. 2020). Here, we present an ancient human genome from Africa and use it to disentangle the effects of recent population movement into Africa. Subsets of African genetic variation found outside of Africa also vary by region, indicating that multiple OOA migrations may have occurred (Rasmussen et al. Several candidate loci under selection have been identified that are likely implicated in the short stature of RHG groups as they overlap with genes associated with bone synthesis (e.g., EHB1 and PRDM5), muscular development (e.g., OBSCN and COX10), and growth hormone synthesis and secretion in the pituitary gland (e.g., HESX1 and ASB14) (Jarvis et al. Im a 100% East African Somali and wanted to know my genetic potential for bodybuilding. 2019). 2021). A individual who possesses a enhanced genotype is well-suited to the sport of bodybuilding. 2019; Anagnostou et al. Possibly, Khoe-San were the only inhabitants of southern Africa for much of its prehistory (Schlebusch et al. The Khoe-San are basal to all other human lineages with an estimated divergence time of 300200 kya (Schlebusch et al. 2022). 2019). Furthermore, consistent with patterns observed in the Americas (Micheletti et al. This requires meaningful engagement of community stakeholders on ethical, legal, and social issues as well as the communication of results, to guarantee that the benefits outweigh the risks (Lemke et al. Why do East African men have bigger muscles? Furthermore, variants that are rare on a global level (<1% frequency) are more frequently found to be common in African populations, that is, there is an excess of variants exclusively found in Africans (Auton et al. 2019; Fatumo et al. 2017; Prendergast et al. 2017; Hollfelder et al. 2017). 2017). 2012; Schlebusch and Jakobsson 2018; Gopalan et al. Nonetheless, African populations are connected via gene flow, which can serve as a potent source of adaptive variation. The Maghrebi component is represented by 15,000-year-old Paleolithic individuals from Taforalt, Morocco, whose ancestry is best modeled as a mix of an early Holocene Middle Eastern (63.5%), that is, Levantine Natufians, and a sub-Saharan component (Van De Loosdrecht et al. Another example of adaptation to extreme conditions are RHG groups, who evolved a short stature (mean adult height <160cm). Overall, these findings demonstrate that recent admixture involved sex-biased gene flow. 1. A little less than 1% of Afrikaner genes have an East Asian (Chinese or Japanese) origin. 2020). found that the East African LP allele is largely absent from ancient pastoralist individuals from Kenya and Tanzania, indicating that east African pastoralists were lactose intolerant as recently as 31 kya (Prendergast et al. 2018). One key example of this involves tuberculosis, a disease that has particularly severe infections in the SAC population (Chimusa et al. 2010; Petersen et al. The remaining traditional huntergatherer groups in Africa can be broadly grouped into three major groups: Khoe-San, eastern African huntergatherers (EAHG), and rainforest huntergatherers (RHG). For full access to this pdf, sign in to an existing account, or purchase an annual subscription. This suggests that the benefits of adaptive EGLN1 haplotypes may extend beyond high-altitude conditions. There is not a lot of fats in the East African diet. Thus, this study indicates that admixture of Khoe-San groups with eastern African pastoralists occurred at least 1.2 kya (fig. Mitochondrial DNA structure in North Africa reveals a genetic discontinuity in the Nile Valley, Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa, African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations, Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation, A roadmap to increase diversity in genomic studies, Demographic and selection histories of populations across the Sahel/Savannah belt, Anthropological genetics perspectives on the transatlantic slave trade, Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe, Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa, African ancient DNA research requires robust ethics and permission protocols, Exploring the relationships between genetic, linguistic and geographic distances in Bantu-speaking 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analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations, Whole-exome analysis in Tunisian Imazighen and Arabs shows the impact of demography in functional variation, Population history of North Africa based on modern and ancient genomes, Tracing pastoralist migrations to Southern Africa with lactase persistence alleles, Low and differential polygenic score generalizability among African populations due largely to genetic diversity, The Simons Genome Diversity Project: 300 genomes from 142 diverse populations, The demographic response to Holocene climate change in the Sahara, Fast and flexible estimation of effective migration surfaces perry, GH, alves, I, & tansey, W, editors, Cattle before crops: the beginnings of food production in Africa, The critical needs and challenges for genetic architecture studies in Africa, A continuum of admixture in the western hemisphere revealed by the African 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colonization of the Americas, Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool, Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians, The genomic prehistory of peoples speaking Khoisan languages, The impact of agricultural emergence on the genetic history of African rainforest hunter, Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America, The demographic and adaptive history of Central African hunter, Genetic structure of a unique admixed population: implications for medical research, Divorcing the Late Upper Palaeolithic demographic histories of mtDNA haplogroups M1 and U6 in Africa, Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel, African genetic diversity and adaptation inform a precision medicine agenda, Genetic variants associated with warfarin dose in AfricanAmerican individuals: a genome-wide association study, Diet and the evolution of human amylase gene copy number variation, Complex patterns of genomic admixture within Southern Africa, Challenges of accurately estimating sex-biased admixture from X chromosomal and autosomal ancestry proportions, The genetic prehistory of Southern Africa, Possible ancestral structure in human populations, Ancient DNA reveals a multistep spread of the first herders into sub-Saharan Africa, The historical spread of Arabian pastoralists to the Eastern African Sahel evidenced by the lactase persistence 13,915*G allele and mitochondrial DNA, Sahelian pastoralism from the perspective of variants associated with lactase persistence, Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort, Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity while contributing to health and disease, A weakly structured stem for human origins in Africa, Genetic origins of lactase persistence and the spread of pastoralism in Africa, An aboriginal Australian genome reveals separate human dispersals into Asia. 2013; Johnson et al. 2014; Rees et al. During the Neolithization, North African populations admixed with European Neolithic groups. Since they never had bad diseases which lead to skin tissue rupturing, their skin is able to repair quickly. Matjuda EN, Engwa GA, Anye SNC, Nkeh-Chungag BN, Goswami N. Pereira L, Mutesa L, Tindana P, Ramsay M. Schlebusch CM, Sjdin P, Skoglund P, Jakobsson M. Swart Y, Uren C, van Helden PD, Hoal EG, Mller M. Swart Y, van Eeden G, Sparks A, Uren C, Mller M. Tallman S, Sungo M das D, Saranga S, Beleza S. Vicente M, Jakobsson M, Ebbesen P, Schlebusch CM. 2017). 2022). For a comprehensive review of Sahelian populations demographic history, including Niger-Congospeaking populations, we refer to ern et al. 2022). 2014, 2017). 2018; Sengupta et al. Wang K, Mathieson I, OConnell J, Schiffels S. Oxford University Press is a department of the University of Oxford. WebGenetics matter for pretty much any sport, and this especially applies to strength training. Despite recent progress, African populations are still dramatically underrepresented in genetic studies, and more studies of African genetic variation and population structure are needed. We also thank Matt Hansen, Carina Schlebusch, Cesar Fortes-Lima, and Lara R. Arauna for their assistance in accessing African genomic data sets. 2020; Matjuda et al. 1. Training more diverse scientists and building research capacities on the African continent not only leads to better research but may also help to address the lack of diversity in study cohorts (Hindorff et al. Nevertheless, African huntergatherers have the highest level of genetic diversity of extant populations and represent the most deeply branching human lineages even after accounting for recent admixture (Henn et al. 2021). 2015; Mallick et al. HaplotypeA set of linked genetic variants that are coinherited. 2015). (2021). For example, the Amahara people have adapted to low barometric pressure and hypoxia in the Ethiopian Highlands over the past 5,000 years. RHG groups comprise genetically diverse populations in equatorial Africa, which are often further subdivided into western (e.g., the Baka) and eastern (e.g., the Mbuti) RHG groups (Patin and Quintana-Murci 2018). 2022). 2017; Novkov et al. 2012); BHLHE41, a gene that is involved in hypoxia response and circadian rhythm (Huerta-Snchez et al. 2017; Lopez et al. Nevertheless, different genetic ancestries tend to cluster geographically (fig. 3. How the climate affects the Africans body size. 2014; Vicente, Priehodov, et al. Intriguingly, EGLN1 has also been implicated in selection scans of the click-speaking Sandawe people, who are traditional foragers from Tanzania (Lachance et al.

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